Drug Information

Drug General Information
Drug ID
D09TDZ
Former ID
DIB002343
Drug Name
AF-802
Synonyms
CH-5424802; ALK inhibitor (NSCLC), Chugai
Drug Type
Small molecular drug
Indication Non-small cell lung cancer [ICD10:C33-C34] Phase 2 [524315], [542705]
Company
Chugai pharma; Roche
Formula
C30H34N4O2
InChI
InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
InChIKey
KDGFLJKFZUIJMX-UHFFFAOYSA-N
PubChem Compound ID
49806720
PubChem Substance ID
103778663, 121116820, 123050635, 124968641, 136345847, 136367502, 136966843, 144115816, 152159573, 152255079, 152258416, 160647252, 162011594, 162205135, 163643281, 164041825, 174006440, 174526912, 185973183, 198968336, 223366072, 223382853, 223705048, 224579110, 227163650, 242060208, 249734006, 249814476, 252110120, 252151320, 252160538, 252215127, 252444922, 252451665, 252811243
Target and Pathway
Target(s) ALK tyrosine kinase receptor Target Info Inhibitor [531479]
KEGG Pathway Non-small cell lung cancer
WikiPathways Differentiation Pathway
References
Ref 524315ClinicalTrials.gov (NCT01871805) A Study of CH5424802/RO5424802 in Patients With ALK-Rearranged Non-Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 542705(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7739).
Ref 531479CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679-90.

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