Drug General Information
Drug ID	D09TEI
Former ID	DIB008761
Drug Name	ReN-1869
Synonyms	Neurin project, ReNeuron; ReN-0189; NNC-05-1869; NNC-47-0189
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 2	[547211]
Company	Novo Nordisk Pharmaceuticals Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=CCCN2C[C@H](C(=O)O)CCC2)c2c(CCc3c1cccc3)cccc2
CAS Number	CAS 170149-99-2
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[526246]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547211	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014046)
Ref 526246	ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57.

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