Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09TFB
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| Former ID |
DIB010132
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| Drug Name |
TOFIMILAST
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| Synonyms |
CP-325366; Tofimilast < Prop INN; 9-Cyclopentyl-7-ethyl-3-(2-thienyl)-5,6-dihydro-9H-pyrazolo[3,4-c][1,2,4]triazolo[4,3-a]pyridine
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| Drug Type |
Small molecular drug
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| Indication | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] | Phase 2 | [521675] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C18H21N5S
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| Canonical SMILES |
CCc1nn(C2CCCC2)c3c1CCn4c(nnc34)c5cccs5
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| InChI |
1S/C18H21N5S/c1-2-14-13-9-10-22-17(15-8-5-11-24-15)19-20-18(22)16(13)23(21-14)12-6-3-4-7-12/h5,8,11-12H,2-4,6-7,9-10H2,1H3
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| InChIKey |
DHCOPPHTVOXDKU-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CAMP-specific 3',5'-cyclic phosphodiesterase 4B | Target Info | Inhibitor | [531635] | |
| Type IV phosphodiesterase | Target Info | Inhibitor | [551871] | ||
| CAMP-specific 3',5'-cyclic phosphodiesterase 4A | Target Info | Inhibitor | [531324] | ||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| PathWhiz Pathway | Purine Metabolism | ||||
| References | |||||
| Ref 531324 | GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization. J Pharmacol Exp Ther. 2011 Apr;337(1):145-54. | ||||
| Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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