Drug Information

Drug General Information
Drug ID
D09TPF
Former ID
DAP000979
Drug Name
Molindone
Synonyms
Moban; Molindona; Molindonum; Molindone Monohydrochloride; Moban (TN); Molindona [INN-Spanish]; Molindone (INN); Molindone (MOL); Molindone [INN:BAN]; Molindonum [INN-Latin]; (+-)-Molindone; 3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one; 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Approved [538485], [539311]
Therapeutic Class
Antipsychotic Agents
Structure
Download
2D MOL

3D MOL
Formula
C16H24N2O2
InChI
InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3
InChIKey
KLPWJLBORRMFGK-UHFFFAOYSA-N
CAS Number
CAS 7416-34-4
PubChem Compound ID
23897
PubChem Substance ID
9439, 7784248, 8167438, 10534390, 11467063, 11468183, 11486836, 14799490, 26755691, 29291008, 46504744, 47320783, 47320784, 48289519, 48289520, 48365147, 48416291, 49699386, 49984921, 50111112, 50836898, 57331496, 85209915, 85787545, 90341242, 92723324, 96024914, 99375691, 103167157, 104021724, 104179135, 104359414, 117423090, 117597268, 125562976, 126626997, 126652518, 126663373, 128400085, 131377755, 134223702, 134338250, 134987862, 135650621, 135874693, 137260961, 140261912, 143493298, 152038486, 152235779
SuperDrug ATC ID
N05AE02
SuperDrug CAS ID
cas=007416344
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Binder [536346], [538098]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 538485FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017111.
Ref 539311(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 207).
Ref 536346Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD002083.
Ref 538098Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol Psychiatry. 1998 Mar;3(2):123-34.

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