Drug Information

Drug General Information
Drug ID
D09UEM
Former ID
DIB020356
Drug Name
minodronic acid
Synonyms
YH 529; ONO 5920; BPH 261
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540148]
Structure
Download
2D MOL
Formula
C9H12N2O7P2
InChI
InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
InChIKey
VMMKGHQPQIEGSQ-UHFFFAOYSA-N
PubChem Compound ID
130956
PubChem Substance ID
7843852, 10242764, 12014461, 14874799, 29196193, 29196330, 29309444, 48426327, 53837734, 56374449, 57343615, 75971565, 87457604, 93309669, 99375738, 103314069, 104374011, 124894544, 125823092, 126651847, 126666053, 129496050, 131302852, 135268217, 135649663, 137084388, 141698785, 144206806, 151995601, 160650211, 160655146, 162205070, 162222716, 163416705, 164777754, 164779842, 164779843, 171578885, 175438067, 179322955, 184547763, 186024269, 196109800, 198979870, 206246374, 223589663, 223662192, 224339905, 226511683, 249828272
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [529700]
Farnesyl pyrophosphatesynthetase Target Info Inhibitor [530855]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid BiosynthesisPW000050:Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)R-HSA-191273:Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)WP2706:Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540148(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3164).
Ref 529700Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607.
Ref 530855Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.