Drug General Information
Drug ID
D09VTJ
Former ID
DNC000759
Drug Name
Hyperforin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539810]
Structure
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2D MOL

3D MOL

Formula
C35H52O4
InChI
InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChIKey
IWBJJCOKGLUQIZ-HQKKAZOISA-N
CAS Number
CAS 11079-53-1
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:5834
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [535615]
Pregnane X receptor Target Info Binder [537021]
Prostaglandin G/H synthase 1 Target Info Inhibitor [535615]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosishsa00590:Arachidonic acid metabolism
Platelet activation
NetPath Pathway IL4 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient NetworkWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Pregnane X Receptor pathway
Drug Induction of Bile Acid Pathway
Nuclear ReceptorsWP98:Prostaglandin Synthesis and Regulation
Phase 1 - Functionalization of compounds
Selenium Micronutrient Network
References
Ref 539810(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2764).
Ref 535615Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol. 2002 Dec 15;64(12):1767-75.
Ref 537021Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther. 2009 Apr;329(1):141-9. Epub 2009 Jan 15.

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