Drug General Information
Drug ID	D09WCE
Former ID	DIB006068
Drug Name	IS-159
Drug Type	Small molecular drug
Indication	Migraine [ICD9: 346; ICD10:G43]		Discontinued in Phase 2	[545995]
Company	Immunotech SA
Structure		Download 2D MOL 3D MOL
Formula	C23H27N5O5
Canonical SMILES	[nH]1cc(c2c1ccc(c2)OCC(=O)N[C@H](C(=O)NCC(=O)N)Cc1ccc(c<br />c1)O)CCN
CAS Number	CAS 133790-13-3
PubChem Compound ID	196859
Target and Pathway
Target(s)	5-hydroxytryptamine 1B receptor	Target Info	Modulator
	5-hydroxytryptamine 1D receptor	Target Info	Modulator
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signaling
References
Ref 545995	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005786)

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