Drug General Information
Drug ID
D09XAM
Former ID
DIB018867
Drug Name
APR19
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543233]
Structure
Download
2D MOL
Formula
C21H32F2
InChI
InChI=1S/C21H32F2/c1-13-4-7-17-16-6-5-14-12-15(22)8-10-20(14,2)18(16)9-11-21(17,3)19(13)23/h5,13,15-19H,4,6-12H2,1-3H3/t13-,15+,16?,17?,18?,19+,20+,21+/m1/s1
InChIKey
UEILQXVVJHZGQK-KYFJQHFKSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Progesterone receptor Target Info Antagonist [532304]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 543233(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8662).
Ref 532304A new strategy for selective targeting of progesterone receptor with passive antagonists. Mol Endocrinol. 2013 Jun;27(6):909-24.

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