Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09XUH
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| Former ID |
DIB006696
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| Drug Name |
GASTRAZOLE
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| Synonyms |
JB-95008; 5-[N-[5-[N-(Cycloheptylmethyl)carbamoyl]-1H-benzimidazol-6-ylcarbonyl]-2-fluoro-L-phenylalanylamino]isophthalic acid
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| Drug Type |
Small molecular drug
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| Indication | Duodenal ulcers [ICD10:K25-K27] | Phase 3 | [528144] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C34H34FN5O7
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| Canonical SMILES |
C1CCCC(CC1)CNC(=O)C2=CC3=C(C=C2C(=O)NC(CC4=CC=CC=C4F)C(<br />=O)NC5=CC(=CC(=C5)C(=O)O)C(=O)O)N=CN3
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| InChI |
1S/C34H34FN5O7/c35-26-10-6-5-9-20(26)14-29(32(43)39-23-12-21(33(44)45)11-22(13-23)34(46)47)40-31(42)25-16-28-27(37-18-38-28)15-24(25)30(41)36-17-19-7-3-1-2-4-8-19/h5-6,9-13,15-16,18-19,29H,1-4,7-8,14,17H2,(H,36,41)(H,37,38)(H,39,43)(H,40,42)(H,44,45)(H,46,47)/t29-/m0/s1
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| InChIKey |
CUVGKDWFTDAHSS-LJAQVGFWSA-N
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| CAS Number |
CAS 174610-98-1
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Gastrin/cholecystokinin type B receptor | Target Info | Antagonist | [544049], [551871] | |
| PANTHER Pathway | CCKR signaling map ST | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| References | |||||
| Ref 544049 | Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 April 24; 94(8): 1107-1115. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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