Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09XUY
|
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| Former ID |
DPR000059
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| Drug Name |
Icofungipen
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| Synonyms |
Icofungipen [INN]; PLD 118; PLD118; PLD-118; (1R,2S)-2-Amino-4-methylenecyclopentane-1-carboxylic acid; (1R,2S)-2-amino-4-methylidenecyclopentane-1-carboxylic acid; (1r,2s)-2-amino-4-methylidenecyclopentanecarboxylic acid
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Antifungal Agents
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| Structure |
|
Download2D MOL |
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| Formula |
C7H11NO2
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| Canonical SMILES |
C=C1CC(C(C1)N)C(=O)O
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| InChI |
1S/C7H11NO2/c1-4-2-5(7(9)10)6(8)3-4/h5-6H,1-3,8H2,(H,9,10)/t5-,6+/m1/s1
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| InChIKey |
RKOUGZGFAYMUIO-RITPCOANSA-N
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| CAS Number |
CAS 526194-96-7
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Fungi/Bacteria isoleucyl t-RNA synthetase | Target Info | Modulator | [527528] | |
| References | |||||
| Ref 527528 | Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits. Antimicrob Agents Chemother. 2005 May;49(5):2084-92. | ||||
| Ref 537364 | Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. Epub 2009 May 7. | ||||
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