Drug Information

Drug General Information
Drug ID
D09YVA
Former ID
DNC012228
Drug Name
8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533482]
Structure
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2D MOL

3D MOL
Formula
C15H19N3O
Canonical SMILES
CN1CCN(CC1)C2=NC3=C(C=CC=C3OC)C=C2
InChI
1S/C15H19N3O/c1-17-8-10-18(11-9-17)14-7-6-12-4-3-5-13(19-2)15(12)16-14/h3-7H,8-11H2,1-2H3
InChIKey
XPBCUYLZAWCBJJ-UHFFFAOYSA-N
PubChem Compound ID
44316216
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [533482]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [533482]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [533482]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 533482J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.
Ref 533482J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.

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