Drug Information

Drug General Information
Drug ID
D09ZQX
Former ID
DNC001341
Drug Name
SL65.0155
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 2 [539921], [547240]
Structure
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2D MOL

3D MOL
Formula
C23H25ClN4O4
InChI
InChI=1S/C23H25ClN4O4/c24-18-14-17(20-21(19(18)25)31-13-12-30-20)22-26-28(23(29)32-22)16-7-10-27(11-8-16)9-6-15-4-2-1-3-5-15/h1-5,14,16H,6-13,25H2
InChIKey
MDBNTXARNGRHEV-UHFFFAOYSA-N
PubChem Compound ID
9805719
PubChem Substance ID
16861514, 24113565, 44841714, 47805567, 47880131, 77453400, 135262065, 135651059, 136352138, 137263507, 163417539, 163850518, 172893312, 189053704, 198978062, 202549723, 223532858, 230609868, 242547498, 242769952, 252469079
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [535516]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539921(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 29).
Ref 547240Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014352)
Ref 535516SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties. J Pharmacol Exp Ther. 2002 Aug;302(2):731-41.

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