Drug Information

Drug General Information
Drug ID
D0A1MW
Former ID
DIB018752
Drug Name
aconitine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539689]
Structure
Download
2D MOL
Formula
C34H47NO11
InChI
InChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21+,22-,23+,24+,25-,26?,27+,28-,29+,31+,32-,33+,34-/m1/s1
InChIKey
XFSBVAOIAHNAPC-XTHSEXKGSA-N
PubChem Compound ID
245005
PubChem Substance ID
8357, 105839, 8138304, 8148149, 11408770, 25652328, 30043658, 50223670, 57400419, 85856305, 90471682, 134221761, 134973093, 135652663, 136246086, 137185583, 144205568, 162219967, 163428224, 164263517, 184548376, 226453342, 242517973
Target and Pathway
Target(s) Sodium channel protein type 2 subunit alpha Target Info Activator [533513]
Sodium channel protein type 5 subunit alpha Target Info Activator [532584]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 539689(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2617).
Ref 532584Properties of aconitine-modified sodium channels in single cells of mouse ventricular myocardium. Gen Physiol Biophys. 1986 Oct;5(5):473-84.
Ref 533513Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7.

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