Drug General Information
Drug ID
D0A1QK
Former ID
DNC011181
Drug Name
Isochroman mono-carboxylic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531033]
Structure
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2D MOL

3D MOL

Formula
C18H23NO4S2
Canonical SMILES
C1CSSC1CCCCC(=O)NC2=CC3=C(CC(OC3)C(=O)O)C=C2
InChI
1S/C18H23NO4S2/c20-17(4-2-1-3-15-7-8-24-25-15)19-14-6-5-12-10-16(18(21)22)23-11-13(12)9-14/h5-6,9,15-16H,1-4,7-8,10-11H2,(H,19,20)(H,21,22)/t15-,16+/m1/s1
InChIKey
KRQHPRIBLJFGIT-CVEARBPZSA-N
PubChem Compound ID
Target and Pathway
Target(s) mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [531033]
KEGG Pathway Adherens junction
Insulin signaling pathway
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
Pathway Interaction Database Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling events
Reactome Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
WikiPathways Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signaling
References
Ref 531033Eur J Med Chem. 2010 Sep;45(9):3709-18. Epub 2010 May 15.Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.
Ref 531033Eur J Med Chem. 2010 Sep;45(9):3709-18. Epub 2010 May 15.Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.

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