TTD | Drug: D0A2GI

Drug General Information
Drug ID	D0A2GI
Former ID	DIB020279
Drug Name	LY334362
Synonyms	LY-334362; LY 334362
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539461]
Structure		Download 2D MOL 3D MOL
Formula	C22H20N4O2
InChI	InChI=1S/C22H20N4O2/c23-22(24)26-25-14-17-5-4-8-20(13-17)28-15-16-9-11-19(12-10-16)21(27)18-6-2-1-3-7-18/h1-14H,15H2,(H4,23,24,26)/b25-14+
InChIKey	ROCDIHAUKUGXMY-AFUMVMLFSA-N
PubChem Compound ID	23786508
PubChem Substance ID	47359960, 47510135, 136351106
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Antagonist	[534232]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539461	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 231).
Ref 534232	A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68.

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Drug Information