Drug Information

Drug General Information
Drug ID
D0A5KG
Former ID
DNC007006
Drug Name
2-azido-N6-methyl-9-(beta-D-ribofuranosyl)adenine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528559]
Structure
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2D MOL

3D MOL
Formula
C11H14N8O4
Canonical SMILES
CNC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N=[N+]=[N-]
InChI
1S/C11H14N8O4/c1-13-8-5-9(16-11(15-8)17-18-12)19(3-14-5)10-7(22)6(21)4(2-20)23-10/h3-4,6-7,10,20-22H,2H2,1H3,(H,13,15,16)/t4-,6-,7-,10-/m1/s1
InChIKey
CAQREKOGAXNCLL-KQYNXXCUSA-N
PubChem Compound ID
16094571
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [528559]
Adenosine A3 receptor Target Info Inhibitor [528559]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCRs, Other
References
Ref 528559J Med Chem. 2006 Dec 14;49(25):7373-83.2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.
Ref 528559J Med Chem. 2006 Dec 14;49(25):7373-83.2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.

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