Drug General Information
Drug ID	D0A5MR
Former ID	DNC008666
Drug Name	MK-0354
Drug Type	Small molecular drug
Indication	Discovery agent		Phase 2	[521843], [541103]
Structure		Download 2D MOL 3D MOL
Formula	C7H8N6
InChI	InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
InChIKey	LTQYSJKGRPGMPO-UHFFFAOYSA-N
PubChem Compound ID	11159621
PubChem Substance ID	16238638, 16805639, 23353578, 42214392, 56384673, 75706889, 103644428, 104117335, 104120187, 134345871, 137275966, 139339287, 139339338, 139611238, 139923587, 178102409, 203082864, 224049789, 228045362, 244963044, 245546792, 248827501, 249775763, 249810657, 251963152, 252160268, 252448763
Target and Pathway
Target(s)	Nicotinic acid receptor	Target Info	Inhibitor	[531020]
References
Ref 521843	ClinicalTrials.gov (NCT00337415) MK0354 Clinical Efficacy and Tolerability Study (0354-004). U.S. National Institutes of Health.
Ref 541103	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5784).
Ref 531020	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4472-4. Epub 2010 Jun 10.GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.

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