Drug Information

Drug General Information
Drug ID
D0A5SE
Former ID
DAP001444
Drug Name
Febuxostat
Synonyms
Adenuric; TEI; Uloric; Febuxostat [USAN]; S1547; TMX 67; Tei 6720; TMX-67; Tei-6720; Uloric (TN); Febuxostat (JAN/USAN/INN); TMX-67, Adenuric, Uloric, Febuxostat; 111GE013; 2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID; 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic acid;2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid; 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
Drug Type
Small molecular drug
Indication Hyperuricaemia in gout [ICD9: 274, 790.6; ICD10:E79.0, M10] Approved [530677], [541899]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C16H16N2O3S
InChI
InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
InChIKey
BQSJTQLCZDPROO-UHFFFAOYSA-N
CAS Number
CAS 144060-53-7
PubChem Compound ID
134018
PubChem Substance ID
827254, 4484625, 7848269, 7890737, 10243499, 12014717, 14899120, 29311812, 46506708, 50064429, 53197612, 57344764, 92719385, 93307960, 99431926, 103765728, 104142020, 104253203, 104381153, 118047349, 119526879, 121362144, 124757329, 124893781, 125001903, 125164133, 125645402, 126620851, 126652673, 126667078, 127554532, 134338644, 135089359, 135565727, 135692175, 135697551, 135723459, 136367945, 136920430, 137171680, 141631602, 144075735, 144115972, 144206555, 151981114, 152227348, 152258563, 152344198, 160647398, 160813538
SuperDrug ATC ID
M04AA03
Target and Pathway
Target(s) Xanthine dehydrogenase/oxidase Target Info Inhibitor [530677], [551717]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Retinoate biosynthesis II
KEGG Pathway Purine metabolism
Caffeine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Peroxisome
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Purine metabolism
PathWhiz Pathway Caffeine Metabolism
Purine Metabolism
Reactome Purine catabolism
WikiPathways Oxidative Stress
Effects of Nitric Oxide
Metabolism of nucleotides
Selenium Micronutrient Network
References
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 541899(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6817).
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 551717Clinical pipeline report, company report or official report of Takeda (2009).

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