Drug General Information
Drug ID	D0A5TM
Former ID	DIB001799
Drug Name	SGB-1534
Drug Type	Small molecular drug
Indication	Hypotension [ICD9: 458, 796.3; ICD10:I95]		Discontinued in Phase 2	[544565]
Company	Chugai Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C21H25ClN4O3
Canonical SMILES	n1(c(=O)[nH]c2c(c1=O)cccc2)CCN1CCN(c2c(OC)cccc2)CC1.Cl
CAS Number	CAS 88068-72-8
PubChem Compound ID	122064
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[533371]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544565	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000148)
Ref 533371	Potent alpha-adrenoceptor blocking action of SGB-1534, a new quinazoline antihypertensive agent in vitro experiments. Gen Pharmacol. 1986;17(2):143-9.

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