Drug General Information
Drug ID	D0A5TS
Former ID	DCL001109
Drug Name	EVT-101
Drug Type	Small molecular drug
Indication	Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0]		Discontinued in Phase 2	[548255]
Therapeutic Class	Neurodegenerative
Company	Roche
Structure		Download 2D MOL
Formula	C16H15Cl2F3N4
PubChem Compound ID	72941990
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Antagonist	[536166]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathway
References
Ref 548255	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023880)
Ref 536166	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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