Drug General Information
Drug ID	D0A8IE
Former ID	DNCL003116
Drug Name	AM-831
Drug Type	Small molecular drug
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Discontinued in Phase 1	[547459]
Company	ACADIA Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C7H14ClNO3
Canonical SMILES	COC(=O)C1(CCOCC1)N.Cl
InChI	1S/C7H13NO3.ClH/c1-10-6(9)7(8)2-4-11-5-3-7;/h2-5,8H2,1H3;1H
InChIKey	VNPBPEQYIQVYDP-UHFFFAOYSA-N
PubChem Compound ID	43811077
PubChem Substance ID	83100158, 87166407, 123219523, 125504745, 143460775, 160659184, 162087997, 164199653, 170497886, 185982257, 202822044, 224177163, 227992766, 249735252, 250183937, 252669800
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Agonist	[550322]
	D(2) dopamine receptor	Target Info	Agonist	[550322]
	Acetylcholine receptor	Target Info	Agonist	[550322]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
	cAMP signaling pathway
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
	Nicotine Activity on Dopaminergic NeuronsWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 547459	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016551)
Ref 550322	Clinical pipeline report, company report or official report of Avarx.

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