Drug Information

Drug General Information
Drug ID
D0A8PD
Former ID
DIB018572
Drug Name
2-O-methyl-PAF C-18
Synonyms
2-O-methyl-platelet-activating factor C-18; 2-methyl-C18-PAF; 2-methyloctadecyl PAF
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539139]
Structure
Download
2D MOL
Formula
C29H60NO7P
InChI
InChI=1S/C29H60NO7P/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-27(2)24-34-25-29(37-28(3)31)26-36-38(32,33)35-23-22-30(4,5)6/h27,29H,7-26H2,1-6H3
InChIKey
CIVAIADZNGBFHP-UHFFFAOYSA-N
PubChem Compound ID
132181
PubChem Substance ID
29310393, 57344049, 77186924, 104376870, 135087441, 135651398, 137272111, 241034143
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Agonist [533649]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539139(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1830).
Ref 533649A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31.

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