Drug General Information
Drug ID	D0A8XY
Former ID	DIB013537
Drug Name	Altropane
Synonyms	Carbon-11-Altropane; Iodine-123-Altropane; 11C-Altropane; 123I-Altropane
Drug Type	Small molecular drug
Indication	Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90]		Approved	[522203]
Company	Harvard University
Structure		Download 2D MOL 3D MOL
Formula	C18H21FINO2
Canonical SMILES	C1(C2N(C(CC1c1ccc(cc1)F)CC2)CC=C)C(=O)OC
CAS Number	CAS 127648-29-7
PubChem Compound ID	6440180
Target and Pathway
Target(s)	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[534626]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 522203	ClinicalTrials.gov (NCT00596908) 123I-ALTROPANE Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor. U.S. National Institutes of Health.
Ref 534626	Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41.

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