Drug Information

Drug General Information
Drug ID
D0AD5C
Former ID
DAP000174
Drug Name
Acarbose
Synonyms
Acarbosa; Acarbosum; Glucobay; Glucor; Prandase; Precose; Bay g 5421; Acarbosa [INN-Spanish]; Acarbosum [INN-Latin]; Alpha-Acarbose; Beta-Acarbose; Glucobay (TN); Prandase (TN); Precose (TN); Bay-g-5421; Acarbose (JAN/USAN/INN); Acarbose [USAN:BAN:INN:JAN]; Prandase, Precose, Glucobay, Bay-g 5421, Acarbose; ACI-(1-4)GLD-(1-4)GLC-(1-4)GLB; HMC-(1-4)AGL-(1-4)GLC-(1-4)GLC; 1,4-DEOXY-4-((5-HYDROXYMETHYL-2,3,4-TRIHYDROXYCYCLOHEX-5,6-ENYL)AMINO)FRUCTOSE
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Approved [536361], [541872]
Cardiovascular disorder [ICD10:I00-I99] Phase 3 [536361], [541872]
Therapeutic Class
Hypoglycemic Agents
Company
Bayer
Structure
Download
2D MOL

3D MOL
Formula
C25H43NO18
InChI
InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
InChIKey
XUFXOAAUWZOOIT-SXARVLRPSA-N
CAS Number
CAS 56180-94-0
PubChem Compound ID
444254
PubChem Substance ID
825251, 834618, 7885684, 7888168, 10299511, 12012879, 14964694, 26702476, 36887324, 46391424, 46393315, 49689717, 49853891, 50752736, 57404612, 81062582, 87544180, 92729723, 99437067, 103023822, 103585278, 104038074, 104631735, 123121432, 124757133, 125083567, 125163937, 134338965, 134339490, 135692087, 136368136, 144115532, 144205150, 162023511, 162037530, 170464784, 172386359, 175269637, 175611917, 176484930, 177748581, 178103397, 179116541, 210279189, 210281512, 223984695, 226406984, 241376066, 250133961, 252156703
ChEBI ID
ChEBI:2376
SuperDrug ATC ID
A10BF01
SuperDrug CAS ID
cas=056180940
Target and Pathway
Target(s) Maltase-glucoamylase, intestinal Target Info Modulator [556264]
KEGG Pathway Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways
Carbohydrate digestion and absorption
PathWhiz Pathway Starch and Sucrose Metabolism
WikiPathways Metabolism of carbohydrates
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541872(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6791).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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