Drug General Information
Drug ID	D0AL8T
Former ID	DIB010618
Drug Name	Darbufelone
Synonyms	PD-136095
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Phase 2/3	[532278]
Company	Parke-Davis & Co
Structure		Download 2D MOL 3D MOL
Formula	C18H24N2O2S
Canonical SMILES	N1=C(S/C(=C\c2cc(c(c(C(C)(C)C)c2)O)C(C)(C)C)/C1=O)N.S(=<br />O)(=O)(O)C
CAS Number	CAS 139340-56-0
PubChem Compound ID	6444826
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Modulator	[532278]
	Prostaglandin G/H synthase 2	Target Info	Modulator	[532278]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesisPWY66-393:Aspirin-triggered lipoxin biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosishsa00590:Arachidonic acid metabolism
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	IL4 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Selenium Micronutrient Network
References
Ref 532278	Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9.
Ref 532278	Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9.

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