Drug General Information
Drug ID	D0B0XK
Former ID	DNC000039
Drug Name	1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[536971]
Structure		Download 2D MOL 3D MOL
Formula	C14H13N3O
Canonical SMILES	CCN1C=CC(=O)N2C1=CC(=N2)C3=CC=CC=C3
InChI	1S/C14H13N3O/c1-2-16-9-8-14(18)17-13(16)10-12(15-17)11-6-4-3-5-7-11/h3-10H,2H2,1H3
InChIKey	JEWOUZIOCRUZPT-UHFFFAOYSA-N
CAS Number	CAS 86969-15-5
PubChem Compound ID	135819
PubChem Substance ID	10244064, 12013838, 15342130, 29313259, 50030272, 57345255, 78866072, 103139081, 103228791, 104385436, 117595906, 126438289, 128264910, 134339585, 135089899, 162925777, 241151367
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[536971]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 536971	The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced signaling. Vascul Pharmacol. 2009 Mar-Apr;50(3-4):123-31. Epub 2008 Nov 28.
Ref 536971	The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced signaling. Vascul Pharmacol. 2009 Mar-Apr;50(3-4):123-31. Epub 2008 Nov 28.

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