Drug Information

Drug General Information
Drug ID
D0B2NE
Former ID
DIB018575
Drug Name
2-phenylethylyl-adenosine derivative
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540969]
Structure
Download
2D MOL
Formula
C20H20N6O4
InChI
InChI=1S/C20H20N6O4/c1-21-17-13-18(25-12(24-17)9-8-11-6-4-3-5-7-11)26(10-23-13)20-15(28)14(27)16(30-20)19(29)22-2/h3-7,10,14-16,20,27-28H,1-2H3,(H,22,29)(H,21,24,25)/t14-,15+,16-,20+/m0/s1
InChIKey
PAFSPMXSTBOTSN-KSVNGYGVSA-N
PubChem Compound ID
44598833
PubChem Substance ID
87331353, 103697132, 104141230, 120094196, 178102235
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Agonist [530458]
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, Other
References
Ref 540969(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5600).
Ref 530458Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. J Med Chem. 2009 Dec 10;52(23):7897-900.

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