Drug General Information
Drug ID
Former ID
Drug Name
R-sibutramine metabolite
Indication Depression; Attention deficit hyperactivity disorder [ICD9: 311, 314.00, 314.01; ICD10:F30-F39, F90] Discontinued in Phase 2 [536580]
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Modulator
Sodium-dependent serotonin transporter Target Info Modulator
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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