Drug General Information
Drug ID	D0B4GV
Former ID	DNC007891
Drug Name	4-amino-2H-chromen-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529150]
Structure		Download 2D MOL 3D MOL
Formula	C9H7NO2
Canonical SMILES	C1=CC=C2C(=C1)C(=CC(=O)O2)N
InChI	1S/C9H7NO2/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5H,10H2
InChIKey	AHZAKFLOHIRCDU-UHFFFAOYSA-N
PubChem Compound ID	820807
Target and Pathway
Target(s)	NAD(P)H dehydrogenase [quinone] 1	Target Info	Inhibitor	[529150]
KEGG Pathway	Ubiquinone and other terpenoid-quinone biosynthesis
NetPath Pathway	TCR Signaling Pathway
Pathway Interaction Database	Validated transcriptional targets of TAp63 isoforms
PathWhiz Pathway	Vitamin K Metabolism
WikiPathways	Estrogen metabolism
	Oxidative Stress
	Transcriptional activation by NRF2
	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Aryl Hydrocarbon Receptor Pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Metabolism of amino acids and derivatives
	Aryl Hydrocarbon Receptor
	Dopamine metabolism
	Arylhydrocarbon receptor (AhR) signaling pathway
References
Ref 529150	J Med Chem. 2007 Dec 13;50(25):6316-25. Epub 2007 Nov 14.Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Ref 529150	J Med Chem. 2007 Dec 13;50(25):6316-25. Epub 2007 Nov 14.Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

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