Drug Information

Drug General Information
Drug ID
D0B5BG
Former ID
DNC003646
Drug Name
6-Benzyloxy-9H-purin-2-ylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534565]
Structure
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2D MOL

3D MOL
Formula
C12H11N5O
Canonical SMILES
C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N
InChI
1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
InChIKey
KRWMERLEINMZFT-UHFFFAOYSA-N
PubChem Compound ID
4578
Target and Pathway
Target(s) Methylated-DNA--protein-cysteine methyltransferase Target Info Inhibitor [534565]
WikiPathways DNA Damage Reversal
References
Ref 534565J Med Chem. 1998 Feb 12;41(4):503-8.Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitroor nitroso)pyrimidine derivatives and analogues.
Ref 534565J Med Chem. 1998 Feb 12;41(4):503-8.Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitroor nitroso)pyrimidine derivatives and analogues.

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