Drug Information

Drug General Information
Drug ID
D0B6CC
Former ID
DAP001143
Drug Name
Trimethaphan
Synonyms
Thimethaphan; Trimetaphan; Trimetaphanum; Arfonad (TN); Thieno(1',2':1,2)thieno(3,4-d)imidazol-5-ium, decahydro-2-oxo-1,3-bis(phenylmethyl)-(VAN); 1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium
Drug Type
Small molecular drug
Indication Hypertensive emergencies; Aneurysm [ICD9: 401-405; ICD10:I10, I72] Approved [550667], [551871]
Therapeutic Class
Antihypertensive Agents
Company
Hoffmann La Roche Inc
Structure
Download
2D MOL

3D MOL
Formula
C22H25N2OS+
Canonical SMILES
C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
InChI
1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1
InChIKey
CHQOEHPMXSHGCL-UHFFFAOYSA-N
CAS Number
CAS 7187-66-8
PubChem Compound ID
23576
PubChem Substance ID
9383, 7784243, 8167220, 14852775, 29290711, 46508994, 47731168, 48029580, 50070592, 50071328, 75001564, 87351885, 92098517, 104358862, 117600282, 123092458, 134338388, 134988305, 136350515, 137264017, 143050906, 160964450, 179235954, 241138623
SuperDrug ATC ID
C02BA01
SuperDrug CAS ID
cas=007187668
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-4 chain Target Info Antagonist [537901]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic Neurons
References
Ref 550667Drug information of Trimethaphan, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537901Mechanism of long-lasting block of ganglion nicotinic receptors by mono-ammonium compounds with long aliphatic chain. J Auton Nerv Syst. 1994 Aug;48(3):231-40.

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