Drug General Information
Drug ID	D0B6FM
Former ID	DIB020953
Drug Name	SKF 89748
Synonyms	SK&F 89748; SK&F 89748-A; SK&F-89748
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[468173]
Structure		Download 2D MOL
Formula	C12H17NOS
InChI	InChI=1S/C12H17NOS/c1-14-11-5-6-12(15-2)9-4-3-8(13)7-10(9)11/h5-6,8H,3-4,7,13H2,1-2H3
InChIKey	YCSXMTWSPWKFIE-UHFFFAOYSA-N
PubChem Compound ID	128805
PubChem Substance ID	10242155, 14969834, 29307780, 51267794, 57342736, 85229925, 103092022, 103157887, 103185545, 103936414, 104368999, 117533862, 126436476, 129776963, 135085232, 135651057, 224836638, 234441631, 241163128
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Agonist	[533826]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 468173	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 511).
Ref 533826	Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.

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