Drug Information

Drug General Information
Drug ID
D0B7GU
Former ID
DNC003299
Drug Name
Dihydromorphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538993]
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO3
InChI
InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
InChIKey
IJVCSMSMFSCRME-KBQPJGBKSA-N
CAS Number
CAS 509-60-4
PubChem Compound ID
5359421
PubChem Substance ID
13946, 11653640, 15096631, 39383772, 46506587, 49992800, 57361919, 78298828, 103556978, 128178362, 134977597, 135650183, 137248653, 144206439, 160964809, 198978460, 223439543, 225145639, 226414220, 241108168
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [551379]
Kappa-type opioid receptor Target Info Agonist [551379]
Corticotropin-lipotropin Target Info Agonist [551379]
Delta-type opioid receptor Target Info Agonist [551379]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04916:Melanogenesis
Adipocytokine signaling pathwayhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_2:AndrogenReceptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathwayP04380:Cortocotropin releasing factor receptor signaling pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Pathway Interaction Database IL4-mediated signaling eventsreg_gr_pathway:Glucocorticoid receptor regulatory network
Syndecan-3-mediated signaling events
PathWhiz Pathway Corticotropin Activation of Cortisol Production
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-193048:Androgen biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols
G alpha (s) signalling events
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP2749:Metabolism of steroid hormones and vitamin D
Metabolism of amino acids and derivatives
Peptide hormone biosynthesis
Corticotropin-releasing hormone
Phase 1 - Functionalization of compounds
GPCR downstream signaling
References
Ref 538993(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1616).
Ref 551379Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. Epub 2006 Jun 13.

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