Drug Information

Drug General Information
Drug ID
D0B7KF
Former ID
DIB007406
Drug Name
RG-7152
Synonyms
5-[3-[3-(2-Quinolinylmethoxy)phenoxy]propyl]-1H-tetrazole
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 1 [533831]
Structure
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2D MOL

3D MOL
Formula
C20H19N5O2
Canonical SMILES
C(COc1cccc(OCc2ccc3ccccc3n2)c1)Cc4nn[nH]n4
InChI
1S/C20H19N5O2/c1-2-8-19-15(5-1)10-11-16(21-19)14-27-18-7-3-6-17(13-18)26-12-4-9-20-22-24-25-23-20/h1-3,5-8,10-11,13H,4,9,12,14H2,(H,22,23,24,25)
InChIKey
XDPLTERFGJAMRU-UHFFFAOYSA-N
CAS Number
CAS 107813-63-8
PubChem Compound ID
129968
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Antagonist [533831], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 533831Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. Fundam Appl Toxicol. 1994 Aug;23(2):298-303.
Ref 533831Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. Fundam Appl Toxicol. 1994 Aug;23(2):298-303.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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