Drug Information

Drug General Information
Drug ID
D0B8WQ
Former ID
DIB020219
Drug Name
lisinopril-tryptophan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542818]
Structure
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2D MOL
Formula
C27H34N4O5
InChI
InChI=1S/C27H34N4O5/c28-15-7-6-12-22(30-23(26(33)34)14-13-18-8-2-1-3-9-18)25(32)31-24(27(35)36)16-19-17-29-21-11-5-4-10-20(19)21/h1-5,8-11,17,22-24,29-30H,6-7,12-16,28H2,(H,31,32)(H,33,34)(H,35,36)/t22-,23-,24+/m0/s1
InChIKey
JXNGDSIPMBNTNL-KMDXXIMOSA-N
PubChem Compound ID
45480144
PubChem Substance ID
93577993, 223366216
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [530789]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 542818(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7893).
Ref 530789Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril. Biochem J. 2010 Apr 28;428(1):67-74.

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