Drug General Information
Drug ID	D0B9MY
Former ID	DNC003545
Drug Name	8-Pyridin-4-yl-9H-purine-2,6-diamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534468]
Structure		Download 2D MOL 3D MOL
Formula	C10H9N7
Canonical SMILES	C1=CN=CC=C1C2=NC3=C(N2)C(=NC(=N3)N)N
InChI	1S/C10H9N7/c11-7-6-9(17-10(12)15-7)16-8(14-6)5-1-3-13-4-2-5/h1-4H,(H5,11,12,14,15,16,17)
InChIKey	FRFATUHEQSVWHE-UHFFFAOYSA-N
PubChem Compound ID	457739
Target and Pathway
Target(s)	Dihydrofolate reductase	Target Info	Inhibitor	[534468]
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
References
Ref 534468	J Med Chem. 1997 Sep 12;40(19):3032-9.Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
Ref 534468	J Med Chem. 1997 Sep 12;40(19):3032-9.Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.

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