Drug General Information
Drug ID	D0BA5K
Former ID	DIB011008
Drug Name	Apaxifylline
Synonyms	BIIP-20; U-98950; BIIP-20-XX
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Phase 2	[544358]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Formula	C16H22N4O3
Canonical SMILES	c12c(n(c(=O)n(c1=O)CCC)CCC)[nH]c(n2)C1CC(=O)CC1
CAS Number	CAS 151581-23-6
PubChem Compound ID	60949
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Antagonist	[545800]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544358	Xanthines as Adenosine Receptor Antagonists. Handb Exp Pharmacol. 2011; (200): 10.1007/978-3-642-13443-2_6.
Ref 545800	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779)

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