Drug Information

Drug General Information
Drug ID
D0BD8D
Former ID
DAP000222
Drug Name
Cisapride
Synonyms
Acenalin; Acpulsif; Alimix; Alipride; Cipride; Cisaprida; Cisapridum; Cisapron; Cisawal; Colinorm; Dispep; Enteropride; Esorid; Guptro; Kaudalit; Kinestase; Prepulsid; Presid; Pridesia; Propulsid; Propulsin; Pulsid; Rapulid; Risamal; Risamol; Syspride; Unamol; Unipride; Vomiprid; Vomipride; Alimix Forte; Cisaprida [Spanish]; Cisapridum [Latin]; Propulsid Quicksolv; R 51619; T 1341; Cisaprida [INN-Spanish]; Cisapridum [INN-Latin]; Prepulsid (TN); Propulsid (TN); R-51619; Cisapride (USAN/INN); Cisapride [USAN:BAN:INN:JAN]; Cis-4-Amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-o-anisamide; (+-)-Cisapride; 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide; 4-amino-5-chloro-N-[1-{3-[(4-fluorophenyl)oxy]propyl}-3-(methyloxy)piperidin-4-yl]-2-(methyloxy)benzamide; 4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
Drug Type
Small molecular drug
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Approved [538540], [539528]
Therapeutic Class
Gastrointestinal Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C23H29ClFN3O4
InChI
InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
InChIKey
DCSUBABJRXZOMT-UHFFFAOYSA-N
CAS Number
CAS 81098-60-4
PubChem Compound ID
2769
PubChem Substance ID
9127, 4816531, 7847340, 8151787, 10321734, 11466458, 11467578, 11486095, 14882747, 29221924, 48403970, 48415785, 49875392, 50113158, 51031281, 53786866, 57321449, 80953524, 85209640, 92125386, 92711730, 99418016, 103914221, 103919261, 104301556, 123090165, 125358025, 125663585, 126630574, 126657130, 126669689, 127715812, 131993450, 134337537, 135014802, 135650104, 137101280, 142378524, 144204250, 160963949, 162357904, 162771742, 164807926, 165700416, 170465200, 175611161, 178125987, 179148462, 184551724, 196112081
SuperDrug ATC ID
A03FA02
SuperDrug CAS ID
cas=081098604
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [536685], [536898]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538540FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020210.
Ref 539528(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 240).
Ref 536685The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47. Epub 2008 Apr 12.
Ref 536898Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors. Endocr Relat Cancer. 2009 Mar;16(1):281-90. Epub 2008 Oct 23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.