Drug Information

Drug General Information
Drug ID
D0BF8G
Former ID
DAP001021
Drug Name
Pamidronate
Synonyms
AHPrBP; Amidronate; Aminomux; Aminopropanehydroxydiphosphonate; Aredia; Ribodroat; Acide pamidronique; Acido pamidronico; Acidum pamidronicum; Aminohydroxypropylidene diphosphonate; Novartis brand of pamidronate disodium salt; PAMIDRONATE DISODIUM; PAMIDRONIC ACID; Pamidronate calcium; Pamidronate monosodium; Bisphosphonate 6; Acide pamidronique [INN-French]; Acido pamidronico [INN-Spanish]; Acidum pamidronicum [INN-Latin]; Pamidronic acid (INN); Pamidronic acid [INN:BAN]; Ribodroat (TN); Amino-1-hydroxypropane-1,1-diphosphonate; (3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID; (3-Amino-1-hydroxypropylidene)bisphosphonic acid; (3-Amino-1-hydroxypropylidene)diphosphonic acid; (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid; (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid); (3-amino-1-hydroxypropylidene)-1,1-biphosphonate; (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate; 1-hydroxy-3-aminopropane-1,1-diphosphonic acid; 3-Amino-1-hydroxypropylidene-1,1-diphosphonate
Drug Type
Small molecular drug
Indication Hypercalcemia [ICD9: 275.42; ICD10:E83.5] Approved [536957], [542277]
Therapeutic Class
Antiinflammatory Agents
Structure
Download
2D MOL

3D MOL
Formula
C3H11NO7P2
InChI
InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
InChIKey
WRUUGTRCQOWXEG-UHFFFAOYSA-N
CAS Number
CAS 40391-99-9
PubChem Compound ID
4674
PubChem Substance ID
9599, 634946, 3291059, 5656761, 8152871, 10318359, 11213385, 14798245, 17137002, 25630003, 29215372, 29215373, 29223762, 46504823, 46513038, 47589120, 48416373, 50064771, 50399926, 53790869, 57322390, 85246606, 92217723, 92309049, 93166696, 96024424, 103219240, 104307093, 108146479, 124599993, 125349963, 129624957, 131313809, 131349590, 134338289, 135002241, 135692397, 137004053, 142216111, 144205217, 160963630, 163137156, 163411571, 166219986, 170464689, 175266369, 177012421, 178103833, 179098205, 184546265
SuperDrug ATC ID
M05BA03
SuperDrug CAS ID
cas=040391999
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [536847]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 536957Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27.
Ref 542277(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7259).
Ref 536847Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Aug 30.

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