Drug Information

Drug General Information
Drug ID
D0BI9W
Former ID
DIB016318
Drug Name
Lck tyrosine kinase inhibitors
Synonyms
Lck tyrosine kinase inhibitors (T-cell-mediated automimmune diseases); Lck tyrosine kinase inhibitors (T-cell-mediated automimmune diseases), Merck & Co
Indication Autoimmune diabetes [ICD10:E08-E13] Investigative [552052]
Company
Merck & Co Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1n(c2c(n1)cc(cc2)c1ccncc1)c1ccnc(n1)N[C@H]([C@H]1N(CCN<br />(C1)C(=O)Nc1cccc2c1cccc2)C)C
Target and Pathway
Target(s) Lck tyrosine kinase Target Info Inhibitor [543547]
KEGG Pathway NF-kappa B signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
HTLV-I infection
Primary immunodeficiency
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Parkinson disease
T cell activation
Pathway Interaction Database Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
SHP2 signaling
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signaling
Reactome GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signaling
WikiPathways Notch Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TCR signaling
Costimulation by the CD28 family
References
Ref 552052Disubstituted pyrimidines as Lck inhibitors. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5440-3
Ref 543547(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2053).

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