Drug Information

Drug General Information
Drug ID
D0BM0M
Former ID
DNC008269
Drug Name
N,Ndimethyl milnacipran
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529263]
Structure
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2D MOL

3D MOL
Formula
C17H26N2O
Canonical SMILES
CCN(CC)C(=O)C1(CC1CN(C)C)C2=CC=CC=C2
InChI
1S/C17H26N2O/c1-5-19(6-2)16(20)17(12-15(17)13-18(3)4)14-10-8-7-9-11-14/h7-11,15H,5-6,12-13H2,1-4H3
InChIKey
NMRSWXVEITZBIQ-UHFFFAOYSA-N
PubChem Compound ID
44454695
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [529263]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 529263Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. Epub 2008 Jan 9.Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Ref 529263Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. Epub 2008 Jan 9.Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.

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