Drug Information

Drug General Information
Drug ID
D0C0KJ
Former ID
DIB020247
Drug Name
LTE4
Synonyms
leukotriene E; leukotriene E4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540309]
Structure
Download
2D MOL
Formula
C23H37NO5S
InChI
InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
InChIKey
OTZRAYGBFWZKMX-FRFVZSDQSA-N
PubChem Compound ID
5280879
PubChem Substance ID
8236, 4266070, 7979753, 8143276, 8616419, 16344702, 26756770, 39289868, 48409442, 50111414, 57357904, 74701367, 96099805, 103591347, 104138918, 113854149, 127316814, 127316815, 127316816, 127316817, 127316818, 135651514, 137006567, 138355247, 164228112, 164761568, 178102487, 179293257, 198951720, 198991667, 236466655, 250135039, 252455510, 252467954
Target and Pathway
Target(s) GPR17 Target Info Agonist [529783]
Cysteinyl leukotriene receptor 1 Target Info Agonist [525529]
Leukotriene CysLT2 receptor Target Info Agonist [531263]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540309(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3352).
Ref 525529Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93.
Ref 529783The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One. 2008;3(10):e3579.
Ref 531263Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT?? agonist, N-methyl-leukotriene C?? in calcium reporter and beta arrestin assays. Mol Pharmacol. 2011 Feb;79(2):270-8.

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