Drug Information

Drug General Information
Drug ID
D0C1AY
Former ID
DIB012917
Drug Name
GW-796406
Synonyms
N-[3-Methyl-2(S)-(sulfanylmethyl)butyryl]-4-(1H-pyrazol-1-yl)-L-phenylalanine; 796406
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Phase 1 [527730]
Target and Pathway
Target(s) Neutral endopeptidase Target Info Modulator [549997]
Angiotensin-converting enzyme Target Info Modulator [549997]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's diseasehsa04614:Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 527730Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13. Epub 2005 Sep 6.
Ref 549997Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13.

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