Drug Information

Drug General Information
Drug ID
D0C1WH
Former ID
DAP000626
Drug Name
Letrozole
Synonyms
Femara; Femera; Letoval; Letrozol; Novartis Brand of Letrozole; CGS 20267; CGS-20267; FEM-345; Femara (TN); Letrozole [USAN:INN]; CGS 20267, Femara, Piroxicam, Letrozole; Letrozole (JAN/USP/INN); 1-[Bis-(4-cyanophenyl)methyl]-1,2,4-triazole; 1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole; 4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile; 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile; 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile); 4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile; 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile Letrozole; 4,4'-(1h-1,2,4-triazol-1-ylmethylene) bis-benzonitrile; 4,4'-(1h-1,2,4-triazol-1-ylmethylene)bis-benzonitrile; 4,4'-(1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile; 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
Drug Type
Small molecular drug
Indication Hormonally-responsive breast cancer [ICD9: 174, 175; ICD10:C50] Approved [468263], [536772]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C17H11N5
InChI
InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChIKey
HPJKCIUCZWXJDR-UHFFFAOYSA-N
CAS Number
CAS 112809-51-5
PubChem Compound ID
3902
PubChem Substance ID
10363, 535027, 6899006, 7848027, 7978496, 8152457, 11112889, 11467053, 11468173, 11486806, 12014531, 14799856, 26719850, 29223016, 46386665, 46504610, 46513479, 47440364, 47736586, 47810851, 47959864, 48416161, 49681588, 49699256, 49830389, 49888730, 50100535, 53789196, 56311274, 56312145, 56313556, 56313557, 56313754, 56352886, 57322043, 71821268, 79643905, 81040865, 81092820, 85787542, 92126055, 92308318, 92308918, 92712289, 93166173, 93167148, 99355691, 99437044, 103513368, 103914616
ChEBI ID
ChEBI:6413
SuperDrug ATC ID
L02BG04
SuperDrug CAS ID
cas=112809515
Target and Pathway
Target(s) Cytochrome P450 19 Target Info Inhibitor [535836]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Endogenous sterols
WikiPathways Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compounds
References
Ref 468263(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5209).
Ref 536772New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
Ref 535836Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis. Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):247-51.

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