Drug Information

Drug General Information
Drug ID
D0C5VQ
Former ID
DCL000199
Drug Name
PRX-321
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [522499]
Therapeutic Class
Anticancer Agents
Structure
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2D MOL

3D MOL
Formula
C25H22O10
Canonical SMILES
COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C<br />(C=C5O4)O)O)O)CO)O
InChI
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23-,24-,25+/m0/s1
InChIKey
SEBFKMXJBCUCAI-WAABAYLZSA-N
PubChem Compound ID
1548994
PubChem Substance ID
8653312, 15980112, 32248925, 48416539, 48423991, 48423992, 50156432, 90343356, 103045105, 103723724, 110525152, 126685380, 134338867, 134340531, 138256211, 138632552, 152052267, 162251737, 163641629, 173132020, 179323845, 198953773, 198958212, 227036891, 252216311, 252473416
Target and Pathway
Target(s) Interleukin-4 receptor alpha chain Target Info Agonist [537389]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Inflammatory bowel disease (IBD)
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database p73 transcription factor network
IL4-mediated signaling events
WikiPathways Inflammatory Response Pathway
IL-4 Signaling Pathway
References
Ref 522499ClinicalTrials.gov (NCT00797940) Convection Enhanced Localized Administration of PRX321 With Real-time Imaging for Therapy of Recurrent Glioblastoma (CLARITY-1). U.S. National Institutes of Health.
Ref 537389Convection-enhanced drug delivery of interleukin-4 pseudomonas exotoxin (PRX321): increased distribution and magnetic resonance monitoring. J Pharmacol Exp Ther. 2009 Aug;330(2):520-5. Epub 2009 May28.

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