Drug Information

Drug General Information
Drug ID
D0C8ZD
Former ID
DIB007625
Drug Name
A-71623
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Terminated [543203], [545483]
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C44H56N8O9
InChI
InChI=1S/C44H56N8O9/c1-27-15-9-11-19-31(27)50-42(59)46-22-14-13-21-33(39(56)49-35(25-37(53)54)41(58)52(5)36(38(45)55)23-28-16-7-6-8-17-28)48-40(57)34(51-43(60)61-44(2,3)4)24-29-26-47-32-20-12-10-18-30(29)32/h6-12,15-20,26,33-36,47H,13-14,21-25H2,1-5H3,(H2,45,55)(H,48,57)(H,49,56)(H,51,60)(H,53,54)(H2,46,50,59)/t33-,34-,35-,36-/m0/s1
InChIKey
KNHCBYMGWWTGSO-ZYADHFCISA-N
CAS Number
CAS 130408-77-4
PubChem Compound ID
121964
PubChem Substance ID
7978622, 10239890, 14791595, 15362029, 29302451, 47957444, 48029649, 57339877, 79904397, 104414715, 135077948, 135651964, 144240019, 163326061, 196372078, 241375915, 249617560, 252156490
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Modulator [528494]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543203(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 858).
Ref 545483Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003438)
Ref 528494Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39(3):346-51.

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