Drug Information

Drug General Information
Drug ID
D0CB8W
Former ID
DIB010876
Drug Name
DE-081
Synonyms
Apafant (ophthalmic formulation), Santen
Drug Type
Small molecular drug
Indication Conjunctivitis [ICD9: 372; ICD10:H10] Discontinued in Phase 2 [544551]
Company
Santen Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C22H22ClN5O2S
Canonical SMILES
Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4n12
InChI
1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
InChIKey
JGPJQFOROWSRRS-UHFFFAOYSA-N
PubChem Compound ID
65889
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator [534251]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544551Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000113)
Ref 534251J Pharmacol Toxicol Methods. 1996 Sep;36(1):53-62.Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method.

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