Drug Information

Drug General Information
Drug ID
D0CI9W
Former ID
DIB016364
Drug Name
GSK-334429
Synonyms
GSK-334429; GSK-357868; GSK-678103; H3 antagonists (cognitive disorder); H3 antagonists (cognitive disorder), GlaxoSmithKline
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Investigative [543673]
Company
GlaxoSmithKline plc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
N1(CCN(CCC1)C(=O)C1CCN(CC1)c1cnc(cc1)C(F)(F)F)C(C)C
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [543673]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 543673(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264).
Ref 543673(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264).

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