Drug General Information
Drug ID
D0D0WF
Former ID
DNC000688
Drug Name
GGTI-298
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546421]
Structure
Download
2D MOL

3D MOL

Formula
C27H33N3O3S
Canonical SMILES
CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC3=<br />CC=CC=C32
InChI
1S/C27H33N3O3S/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31)/t19-,25+/m1/s1
InChIKey
XVWPFYDMUFBHBF-CLOONOSVSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Geranylgeranyltransferase I Target Info Inhibitor [538058]
References
Ref 546421Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008012)
Ref 538058The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J Biol Chem. 1997 Oct 24;272(43):27224-9.

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