Drug General Information
Drug ID	D0D0XX
Former ID	DIB011792
Drug Name	LY-290154
Indication	Asthma [ICD10:J45]		Terminated	[546276]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1(ccc2c1c(OCc1nnn[nH]1)ccc2)C(c1cc(/C=C/c2nc3cc(ccc3cc<br />2)Cl)ccc1)CCCc1nnn[nH]1
CAS Number	CAS 140639-61-8
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator
	Leukotriene CysLT2 receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelinsendothelinpathway:Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signaling
References
Ref 546276	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007201)

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